【摘要】目的:探讨自拟止痒散治疗慢性湿疹的效果。方法:选取2019年2月至2021年11月收治的80例慢性湿疹患者为研究对象,随机数字表法分为对照组与观察组各40例,对照组采取氯雷他定及盐酸西替利嗪片、外用炉甘石洗剂等常规用药方案治疗,观察组在对照组基础上加自拟止痒散治疗,对两组治疗效果进行观察。结果:观察组治疗总有效率明显较对照组高(P<0.05);两组治疗前的皮损面积评分、皮损瘙痒评分无明显差异(P>0.05),观察组治疗后上述指标与对照组比较有明显差异(P<0.05)。结论:自拟止痒散用于慢性湿疹治疗中效果满意,可有效减轻症状,值得推广。 【关键词】自拟止痒散;慢性湿疹;临床效果;症状 慢性湿疹是一种常见的皮肤疾病,出现于肛门、手、足、外阴、小腿等多个部位,可发生于各个年龄段,具有反复发作特征;其发生原因可能与内分泌失调、过敏体质、神经功能障碍、遗传等因素相关,若未及时治疗,对严重影响工作与学习[1]。目前,西医针对慢性湿疹主要采取氯雷他定及盐酸西替利嗪片、外用炉甘石洗剂治疗,但是经临床实践发现,多数患者服药后效果难以达到预期,停药后极易复发。中医治疗慢性湿疹的历史悠久,认为该病属于湿疮范畴,多为饮食不节,嗜酒或过食辛辣油腻发动风之品,伤及脾胃,脾失健运而致湿热内蕴,外感风湿热邪,内外两邪共浸淫肌肤而发病,湿邪易耗血伤阴,化燥生风,常年不愈而成慢性[2]。针对此病机,研究处自拟止痒散,本研究为探讨治疗慢性湿疹的有效方案,将自拟止痒散用于临床治疗中,旨在观察其效果。 资料与方法 1.1一般资料 选取2019年2月至2021年11月收治的80例慢性湿疹患者为研究对象,随机数字表法分为对照组与观察组各40例。观察组:男性27例,女性13例,年龄18~71岁,平均年龄(47.25±4.28)岁;病程6个月~3年,平均病程(1.25±0.11)年。对照组:男性25例,女性15例,年龄18~74岁,平均年龄(47.39±4.11)岁;病程6个月~4年,平均病程(1.29±0.15)年。两组基线资料无明显差异(P>0.05),有可比性。 1.2纳入标准及排除标准 纳入标准:符合慢性湿疹诊断标准;病程6个月及以上;年龄≥18岁;皮损局限,边界清晰;非面部皮损。 排除标准:酗酒或药物依赖者;重要脏器功能不全者;伴有其他严重皮肤疾病者;近3个月服用免疫抑制剂或激素类药物者;恶性肿瘤者。 1.3方法 对照组采取常规用药方案治疗,氯雷他定(国药准字H20070030,西安杨森制药有限公司)10mg/次,1次/d;盐酸西替利嗪片(国药准字H20000267,南京圣和药业股份有限公司)10mg/次,1次/d;炉甘石洗剂(国药准字H31022790,上海运佳黄浦制药有限公司)用纱布对患处进行擦洗,每日2次。 观察组在对照组基础上加自拟止痒散(含珍珠、人工牛黄、儿茶),以蒸馏水将自拟止痒散调成糊状剂,将其涂抹于患处,每日1次。 两组均持续治疗2周后观察效果。 1.4观察指标 (1)疗效判断标准:经治疗后,湿疹严重指数(EASI)与瘙痒程度评分下降90%及以上;有效:EASI与瘙痒程度评分下降60%~89%;无效:未达到上述标准。 (2)分别在治疗前后评估皮损面积评分、皮损瘙痒评分按照从无至重度评为0~3分,0分表示无,3分表示重度。 1.5统计学方法 数据录入SPSS23.0软件进行统计学处理,计量资料经t检验,(±s)表示,计数资料以x2检验,率(%)表示,差异有统计学意义为P<0.05。 2. 结果 2.1治疗效果 观察组治疗总有效率明显较对照组高(P<0.05),见表1。 表1 两组临床治疗效果差异[n(%)] 组别 n 显效 有效 无效 总有效 观察组 40 30(75.00) 9(22.50) 1(2.50) 39(97.50) 对照组 40 21(52.50) 10(25.00) 9(22.50) 31(77.50) x2 7.314 P 0.006 2.2皮损情况差异 两组治疗前的皮损面积评分、皮损瘙痒评分无明显差异(P>0.05),观察组治疗后上述指标与对照组比较有明显差异(P<0.05),见表2。 组别 皮损面积评分 皮损瘙痒评分 治疗前 治疗后 […]
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